Scientists discover brain hunger switch

The researchers claim that they have discovered "the mechanism of the brain hunger master switch".
Researchers from the Hebrew University of Jerusalem and the Weizmann Institute of science, working with their British counterparts at Queen Mary College, University of London, have made a breakthrough in weight loss.
According to a press release, the researchers involved in the study published their research results on the 15th, revealing that "the mechanism of action of the master switch for controlling hunger exists in the brain", which is confirmed to be melanocortin 4 receptor (MC4 receptor).
The switch can also be triggered by a drug called "semeratide" that can be used to treat obesity, the report said.
According to reports, MC4 receptors give instructions to our bodies, making us feel full and eliminating our desire to eat more food in a certain period of time. Any mutation in the brain that causes the MC4 receptor to be inactive will cause us to eat more than the recommended amount of food every day.
Throughout the study, researchers managed to separate a large number of pure MC4 receptors from the cell membrane.
The report also said that since the discovery, in order to continue to optimize weight-loss drugs such as semeratide, scientists have been taking MC4 receptor as the research object, because it acts as a switch that can control hunger.
The researchers constructed a three-dimensional model of the MC4 receptor. They found that semeratide causes structural changes in the receptor, which in turn sends signals through neurons to prevent people from feeling hungry.
Feeling hungry for most of the day is a problem for people with a defective appetite control switch in their brain. No matter how much a person eats, such defects can lead to obesity.